Current Research Activities Synthesis of An Inhibitor of the Sodium Pump Obtained From Human Placenta Molecular Modelling and Visualisation of Chemical Structures Molecular Modelling & Structure-Activity Relationships of pyronaridine: Novel Benz-naphthyridine Antimalarials with Activity in vitro and in vivo Correlation of Spectral, Molecular Modelling with Biological Activity of Certain Trioxanes related to Qinghaosu Synthesis of Unusual Trifluralin-Phenylenediamine dimers: Novel Scafolds leading to Compound with Leprostatic and Anticancer Activity Reactions exploiting Ortho-Claisen Rearrangement of Allyl Ethers:Synthesis of Benzofurans and Benzopyrans in Near Superacid Media Synthesis of Dimeric Benzodiazepines Optimisation of the Kelly Process Critical Reviews of Medicines in Current Use

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Molecular Modelling & Structure-Activity Relationships of 4-Amino-mono and bis-Quinolines: Novel Antimalarials with Activity in vitro and in vivo Research team: Dr F M D Ismail, M J Dascombe, S. Alizadeh-Shekalgourabi,Prof. M. G. B. Drew, W. A. Moule, and V. Male Programme of studies: This project involves the synthesis of novel bisquinoline antimalarials, including those related to metaquine, many of which demonstrate activity against the K1 mult-drug resistant strain of P. falciparum (collaborative project with Prof. Wilairat, Dept. of Biochemistry, Mahidol) and activity in vivo against P. berghei. Currently, projects are available to synthesise rationally designed antimalarials molecules which conform to our unpublished bisquinoline receptor map. Ref: a) F. M. D. Ismail, M. J. Dascombe, P. Carr and S. E. North An exploration of the structure-activity relationships of 4-aminoquinolines: Novel antimalarials with activity in-vivo:Journal of Pharmacy and Pharmacology, August 1996, Vol 48 (8), pp 841-850; b) Ismail FMD, Dascombe MJ, Carr P, Merette SAM, Rouault P Novel aryl-bis-quinolines with antimalarial activity in-vivo: Journal of Pharmacy and Pharmacology 50 (5): 483-492 MAY 1998 Medicines for Malaria Venture Ref: Synthesis and Biological Activity of novel antimalarials. S. Alizadeh-Shekalgourabi. (2001) Ph.d Thesis, in progress.

	conformer of Chloroquine, a compound encountering drug resistance in South-East Asia, Sub-Saharan Africa and South America. Molecules Maintained By FMDISMAIL Head of Molecular Modelling, Medicinal Chemistry Research Group.