Current Research Activities Synthesis of An Inhibitor of the Sodium Pump Obtained From Human Placenta Molecular Modelling and Visualisation of Chemical Structures Molecular Modelling & Structure-Activity Relationships of 4-Amino-mono and bis-Quinolines: Novel Antimalarials with Activity in vitro and in vivo Molecular Modelling & Structure-Activity Relationships of pyronaridine: Novel Benz-naphthyridine Antimalarials with Activity in vitro and in vivo Correlation of Spectral, Molecular Modelling with Biological Activity of Certain Trioxanes related to Qinghaosu Synthesis of Unusual Trifluralin-Phenylenediamine dimers: Novel Scafolds leading to Compound with Leprostatic and Anticancer Activity Synthesis of Dimeric Benzodiazepines Optimisation of the Kelly Process Critical Reviews of Medicines in Current Use

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Reactions exploiting Ortho-Claisen Rearrangement of Allyl Ethers:Synthesis of Benzofurans and Benzopyrans in Near Superacid Media Research team: F. M. D. Ismail and R.Mahmood Programme of studies: Syntheses of Vitamin E, a powerful chain breaking lipophilic antioxidant, and it's analogues have been in progress in our laboratories for several years and are aimed at producing compounds that can prevent cancer, slow down the ageing process and decelerate head trauma from both accidents and surgical procedures. In addition, various 5-aminofurans and 6-aminopyrans which have greater antioxidant activity than their bioisosteric oxygen counterparts have been constructed. Ref: Versatile Synthesis of Benzopyrans via Ortho-Claisen Rearrangement of Allyl Ethers. F. M. D. Ismail*, M. J. Hilton and M. Stefinovich. (1992) Tetrahedron. Lett. Vol. 33 (26) pp 3795-3796. Ref: Synthesis of vitamin E Analogues. R Mahmood. (2001) Ph.d Thesis, in progress.

Vitamin E has a flexible Phytyl tail, reminiscent of Archae bacterial lipids Molecules Maintained By W.A.Moule (B.Sc, Hons), Head of Molecular Modelling, Medicinal Chemistry Research Group.