|
|
Synthesis of An
Inhibitor of the Sodium Pump Obtained from Human
Placenta
Research team: Dr F. M. D. Ismail &
Dr. P.G. Evans |
![]() |
|
Programme of studies:
This project involves the synthesis of novel bufenolide
steroids which can inhibit human Na+/K+ ATPases. We have
recently
discovered
an endogenous biochemical pathway that produces these
substances in volume expanded patients. Various routes to late
stage intermediates from androsterone acetate and pregneolone
are now complete.
Ref:
P. J. Hilton, R. W. White, G. A. Lord, G. V. Garner, D. B.
Gordon, M. J.Hilton, L. H. Forni, W. McKinnon, F. M. D.
Ismail*, M. Keenan, K. Jones and W. E. Morden, Lancet, Vol.
348, Number 9023, Saturday 3rd August, 1996, pp 303-306.
ScienceDirect
Abstract/HTML/PDF
Ref: Synthesis of Hypertension Inducing Steroids1. in
prep.
 |
 |
| Dr Philip Evans in The Medicinal
Chemistry Research Group Laboratories |
Lowest energy
conformer of
Bufenolide
a potent hypertension inducing substance
related to the compound isolated from the human
placenta
Molecules Maintained By
FMDIsmail,
SUbject Leader,
Medicinal Chemistry
Research
Group. | | 
SCHOOL OF PHARMACY AND CHEMISTRY:
Medicinal Chemistry Research Group 
