Ismail Group Publications & Research Activity If you require a reprint of any of our publications please email us your details. 2010 Poster & Abstract: Pulmonary delivery of encapsulated chloroquine phosphate using polyester polymer-based microparticles for potential treatment of lung cancers. H M Tawfeek, F. M. D. Ismail, G. A. Hutcheon, I. Y. Saleem. DDL 21 (Drug Delivery to the Lungs 21). Wednesday 8th – Friday 10th December 2010. Edinburgh International Conference Centre (EICC), UK. LC-MS & DFT Investigations of Cryptolepis Sanginolenta Root Extracts. Ismail, F. M. D.; Cox, A. H.; Dempster NM; Ford JL; Dascombe, M. J.; Drew, M. G. B. Journal of Pharmacy & Pharmacology, Volume: 62 (10) Special Issue: Sp. Iss. SI Pages: 1489-1490; Published: OCT 2010. PDF file Podium presentation (and poster presentation) on - further details about the session are available on the UK-Pharmsci website (http://www.ukpharmsci.org)". Thursday 2nd September during the 13.15 - 15.00 Medicinal Chemistry - Natural Products session: LC-MS & DFT investigations of Cryptolepis sanguinolenta Root Extracts F.M.D. Ismail, A.H. Cox, N.M. Dempster, J.L. Ford, M.J. Dascombe, M.G.B. Drew. UK-PharmSci 2010 1st - 3rd September 2010,East Midlands Conference Centre, The University of Nottingham, University Park, Nottingham NG7 2RD UK Quantification of Haem:Antimalarial Drug Receptor Geometry by Crystallography, DFT, Spectroscopic and Spectrometric Methods in vitro and in silico. F.M.D. Ismail , J.L. Ford , N.M. Dempster , G. Edwards , H. Morris 1, . Saleem , A. Alrawahi , M.Azam ,M.J. Dascombe , M. Smith1,, A.W. Parker , I.P. Clark , S. Alizadeh-Shekalgourabi , M.G.B. Drew.presented at: BMSS2010: Mass Spectrometry in a Changing World, 5th – 8th September 2010 Cardiff City Hall. Poster & Abstract. Tuesday 7th September. Fyaz M. D. Ismail,James L. Ford, Nicola M. Dempster, Harry Morris, Mudassar I. Azam, Michael J. Dascombe, Mathew Smith, Anthony W. Parker, Ian P. Clark & Michael G. B. Drew. Oral & Poster Presentation. Quantification of Heam:Antimalarial Drug Receptor Geometry by Crystallography, DFT and Spectroscopic Methods in vitro and in silico; Lasers for Science Facility User Meeting. The Annual Lasers for Science Facility (LSF) User Meeting,STFC, The Cosener’s House, Abingdon. 27th-29th April 2010: http://www.clf.rl.ac.uk/News+and+Events/14802.aspx 2009 Synthesis and Biological Evaluation of New Ozonides with Improved Plant Growth Regulatory Activity. Luiz C. A. Barbosa, Clia R. A. Maltha, Raphael C. Cusati, Rbson R. Teixeira, Filipe F. Rodrigues, Antnio A. Silva, Michael G. B. Drew and Fyaz M. D. Ismail J. Agric. Food Chem. 2009, 57, 10107–10115: SM PDF file Oral Presentation & Abstract: F. M. D. Ismail, N. M. Dempster & J.L. Ford Rapid and efficient isolation of cryptolepine from Cryptolepis sanguinolenta using focused microwave extraction methods: a haem-binding antimalarial; Journal of Pharmacy & Pharmacology, 2009, Supplement A9; Oral presentation at the BPC Conference 2009 Science; Manchester Central Convention Complex, 7th -9th September 2009: HTML/PDF PDF file HTML/PDF Talk Invited review: Aziridine alkaloids as potential therapeutic agents Fyaz M. D. Ismail, Dmitri O. Levitsky and Valery M. Dembitsky, Europ. J. Med. Chem., vol 44 (9) 3373-3387/ 14 May 2009; Available on line 22 May 2009. HTML/PDF PDF file Invited review: Modulation of drug pharmacokinetics and pharmacodynamics by fluorine substitution. Fyaz M. D. Ismail; Michael G. B. Drew & Michael J. Dascombe. Chimica Oggi / Chemistry Today, vol 27 (3) 16-20/ May/June 2009 - Focus on Fluorine chemistry. HTML/PDF PDF file Invited Lecture: “Rational & Rapid drug design of cost effective antimalarials: interception of heme biopolymerisation within Plasmodium falciparum”: Dr Fyaz M. D. Ismail; School of Pharmacy and Biomolecular Sciences.Research Seminars Semester 2 , 2009; Wednesday 28th January, 13.00-14.00 Lecture Room 323. A Pulse radiolysis study of free radicals formed by one electron oxidation of the antimalarial drug pyronaridine. Fyaz M. D. Ismail, Michael G.B.Drew, Suppiah Navaratnam and Roger H. Bisby. Research on Chemical Intermediates, (2008) 35:4,363-377. Special PULS2008 conference issue, Accepted 5 December;Online publication date: 1-May-2009 HTML/PDF PDF file Supp Matt PDF file Mathew Smith, undertaking a placement at Liverpool John Moores University was a recipient of the Shell UK Special Award for Science. Mathew's project developed efficient microwave-synthesis methods for creating anti-malarial drugs useful in vivo. HTML/PDF His work was presented at the Big bang Event. HTML/PDF The new National Science Competition is an initiative of the Department for Innovation, Universities and Skills, being coordinated by the British Science Association, as a response to a recommendation in Lord Sainsbury’s report ‘The Race to the Top’. More information is available at www.nationalsciencecompetition.org 2008 Microwave Accelerated Chemical Synthesis of Antimalarials active in vivo: Probes for Unraveling Antimalarial Drug Action. Mathew Smith, Michael G. B. Drew, Michael J. Dascombe, Nicola G. Dempster, Philip Riby,James L. Ford & Fyaz M. D. Ismail*. Nuffield Celebration Evening – 15 October 2008. Liverpool Football Club, Centenary Stand, Liverpool Merseyside, U. K. PDF file Pulse radiolysis and Density functional Theory studies of the benznaphthyridine antimalarial drug pyronaridine. Roger H. Bisby, Fyaz M. D. Ismail, and Suppiah Navaratnam.UK Synchrotron Radiation User Meeting 2008, 11-12 September 2008 STFC Daresbury Laboratory, Keckwick Lane, Daresbury, Warrington, Cheshire WA4 4AD, U. K. PDF file A pulse radiolysis study of the antimalarial drug pyronaridine. Roger H. Bisby, Fyaz M. D. Ismail, and Suppiah Navaratnam. 8th International Conference on Pulse Investigations in Chemistry, Biology and Physics PULS'2008 September 6 - 12, 2008, Kraków, Poland. PDF file 2007 Seasonal variation in the composition of volatile oils from Schinus terebinthifolius Raddi by L.C.A. Barbosa, A.J.Demuner, A.D.Clemente,& F.M.D.Ismail, Quim. Nova, 2007, 30 (8) 1959-1965. PDF file de novo Identification and Stability of the Artemisinin Pharmacophore: Studies of the Reductive Decomposition of Deoxyartemisins and Deoxyarteethers and the Implications for the Mode of Antimalarial Action Drew, M. G. B.; Metcalfe, J.; Dascombe, M. J.; Ismail, F. M. D. Journal of Molecular Structure: THEOCHEM, (2007), 823, 34–46. PDF file Comparative study of the essential oils of seven Melaleuca (Myrtaceae) species grown in Brazil. Cleber J. Silva, Luiz C. A. Barbosa, Célia R. A. Maltha, Antônio L. Pinheiro, Fyaz M. D. Ismail. Flavour and Fragrance Journal. (2007), 22 (6) 474 - 4787. HTML/PDF PDF file Rational Design Strategies for the Development of Synthetic Quinoline and Acridine Based Antimalarials. Michael J. Dascombe, Michael G.B. Drew, Philip G. Evans, Fyaz M.D. Ismail.Frontiers in Drug Design & Discovery, (2007), 3, 559-609. HTML/PDF PDF file Synthesis and structural characterization of two nostoclide analogues. R.R. Teixeira, L.C.A. Barbosa, J.O. Santana, D.P. Veloso, J. Ellena, A.C. Doriguetto, M.G.B. Drew and F.M.D. Ismail. Journal of Molecular Structure, (2007), 837, (1-3), 197-205. HTML/PDF PDF file 2006 Reactions of Artemisinin and Arteether with Acid: Implications for Stability and Mode of Antimalarial Action Drew, M. G. B.; Metcalfe, J.; Dascombe, M. J.; Ismail, F. M. D. J. Med. Chem.; 2006, 49(20),6065-6073. HTML/PDF PDF file 2005 Antimalarial Drugs based on artemisinin: DFT calculations on the principal reactions. Michael G.B. Drew, John Metcalf and Fyaz M.D. Ismail. Journal of Molecular Structure: Theochem, (2005), 756,87-95. HTML/PDF PDF file Intramolecular reactions of free radicals formed from artemisinin. Evgeny. T. Denisov, Taisa Denisova, Fyaz M. D. Ismail. International Journal of Chemical Kinetics, (2005) 37 (9),554-565. HTML/PDF PDF file Poster Presentation: Fyaz M. D. Ismail*, Michael J. Dascombe*, Michael G. B. Drew*, Harry Morris, Prapon Wilairat, Saranya Auparakkitanon, Wendy A. Moule, Said Alizadeh-Shekalgourabi, Philip G. Evans, Michael Lloyd, Anthony M. Dyas, Pamela Carr and L. Suttcliffe. Mapping Functional Antimalarial Pharmacophores as a Useful Tool for the Rapid Discovery of Drugs Effective In Vivo: Design, Construction, Characterization, and Pharmacology of Weakly Basic Azacycles, Gordon Conference: Malaria August 21-26, 2005, Queen's College, Oxford, UK. HTML/PDF M.J. Dascombe, M.G.B.Drew, H. Morris, P. Wilairat, S. Auparakkitanon, W. A. Moule, S. Alizadeh-Shekalgourabi, P. G. Evans, M. Lloyd, A. M. Dyas, P. Carr, Fyaz M. D. Ismail. :"Mapping antimalarial pharmacophores as a useful tool for the rapid discovery of drugs effective in vivo: design construction, characterisation and pharmacology of metaquine". J. Med. Chem., 48 (17), 5423 -5436, 2005"” HTML/PDF PDF file Supplementary Material F. M. D. Ismail : Invited Lecture: Accelerating Antimalarial Drug Discovery Using focused Microwaves: Discovery and Synthesis of Metaquine. One day Joint Symposium by The Royal Society of Chemistry Liverpool section & Northwest Analytical Division "The applications of microwaves in synthetic and analytical chemistry" At Liverpool John Moores University Wednesday 23rd March 2005. Right Hon. Secretary's Report F. M. D. Ismail et al. : Poster Presentation " Identification and Synthesis of Bisquinoline antimalarials". One day Joint Symposium by The The Royal Society of Chemistry Liverpool section & Northwest Analytical Division "The applications of microwaves in synthetic and analytical chemistry" At Liverpool John Moores University Wednesday 23rd March 2005. 2004 Characterisation and quantification of phenolic antioxidants using the “Oxygen Radical Absorbance Capacity” (ORAC) assay for antioxidants. Rachel Brooke, Roger H. Bisby and Fyaz M. D. Ismail. Free Radicals and Excited States in Aqueous and Non-Aqueous Solutions;27th – 29th October 2004 CCLRC Daresbury Laboratory. A meeting of the Free Radical Research Facility @ Daresbury (http://www.frrf.dl.ac.uk/) sponsored by the European Commission’s “Transnational Access to Major Research Infrastructures – Enhancing Access to Research Infrastructures – Human Potential Programme” HTML/PDF A DFT study of free radicals formed from artemisinin and related compounds Michael G.B. Drew,John Metcalf and Fyaz M.D. Ismail Journal of Molecular Structure: Theochem, (2004) 711, (1-3),95-105. HTML/PDF PDF file The effects of arm cranking exercise and training on platelet aggregation in male spinal cord individuals Thrombosis Research, (2004) 113, (2), 129-136. Mahmoud S. El-Sayed, Ali Younesian, Khalid Rahman, Fyaz M. Ismail and Zeinab El-Sayed Ali HTML/PDF PDF file Unraveling the mechanism of 4-aminoquinoline antimalarial action. Ismail F. M. D.; Drew, M. G. B.; Dascombe, M. J.;Clark,I. P.;Parker, A. W. Central Laser Facility, CCLRC Annual Report (2004) 119-120 PDF file 2003 Fyaz M. D. Ismail:Synthesis of Putatative Antimalarials 2,3-dioxa-bicyclo[3.3.1]nonan-7-one using thiol mediated radical cascades. Fyaz M. D. Ismail. Free Radicals and Excited States in Chemistry and Biochemistry;19th -21st May 2003 CCLRC Daresbury Laboratory. A meeting of the Free Radical Research Facility @ Daresbury (http://www.frrf.dl.ac.uk/) sponsored by the European Commission’s “Transnational Access to Major Research Infrastructures – Enhancing Access to Research Infrastructures – Human Potential Programme” HTML/PDF Invited Lecture: Fluoropharma: Important fluorinated Drugs in Experimental and Clinical Use" Fluorine Technology Bureau meeting, 16th May 2003, University of Manchester, Institute of Science & Technology, Weston Centre, Manchester, U.K. HTML/PDF 14th East of England Medicinal Chemistry Symposium, RSC Biological & Medicinal Chemistry Sector (Industrial Affairs Division) 10/04/03, Fielder Centre, University of Hertfordshire, Hatfield, UK 2002 BBC Talent's Science on Screen: Shortlisted as Presenter for Tomorrow's World, 10th June 200om, Peble Mill, BBC Birmingham/British Broadcasting Corporation, White City 201, Wood Lane, London W12 &TS. HTML/PDF Invited Review: Important fluorinated drugs in experimental and clinical use Ismail, F.M.D. J. Fluorine Chemistry. 118 (1-2): 27-33 DEC 1 2002 HTML/PDF PDF file Synthesis of benzofurans and benzopyrans. (BL: DXN054428) Mahmood, R., 2002, D5c Ph.D., Hertfordshire, 52-3924 Abstract The characterisation of nicotine binding sites on leukocytes. (BL: DXN058941) Morgan, D., 2002, G5c Ph.D., Hertfordshire, 52-10587 Abstract Antagonism of immunostimulatory CpG-oligonucleotides by 4-aminoquinolines and other weak bases:Patent Number: US6479504Publication date: 2002-11-12 Inventor(s): BARLIN GORDON B (AU); ISMAIL FYAZ M D (GB); MACFARLANE DONALD E (US); STREKOWSKI LUCJAN (US); MANZEL LORI (US) Applicant(s): UNIV IOWA RES FOUND (US); US DEPT OF VETERANS AFFAIRS (US); GEORGIA STATE UNIVERSITY RES F (US)" HTML/PDF Manzel L, Strekowski L, ISMAIL F.M.D., Barlin, GB, Manzel L, Macfarlane DE Int. PCT Application: Antagonism of Immunostimulatory CPG-oligonucleotides by 4-aminoquinolines and other weak bases. WO0076982: Publication date: 2002-12-16: Inventor(s): BARLIN GORDON B (AU); ISMAIL FYAZ M D (GB); MACFARLANE DONALD E (US); STREKOWSKI LUCJAN (US); MANZEL LORI (US) Applicant(s): UNIV AUSTRALIAN (AU); UNIV IOWA RES FOUND (US); US DEPT OF VETERANS AFFAIRS (US); GEORGIA STATE UNIVERSITY RES F Canadian Patent HTML/PDF Poster Presentation: Ismail, F. M. D., Banin, M.; Khan, P. Chi Li; Tuladhar, R.; Winter, B. WR238605. Gordon Conference: Malaria August 5-10, 2001, Queen's College, Oxford, UK. 2001 2001 UOA: Pharmacology: RAE submission (University of Hertfordshire) to HEFCE : Fyaz M. D. Ismail. HTML/PDF Shah, D.. ISMAIL F.M.D., Invited Lecture, University of Hertfordshire: Drug metabolism study of a normal antimalarial using HPLC analysis "metaquine" using HPLC analysis. Nyandoro, M; Carr, P.; ISMAIL F.M.D., Invited Lecture, University of Hertfordshire: Molecular modelling and structure activity relationships of amodiaquine analogues. Poster Presentation: M.J. Dascombe, Fyaz M. D. Ismail, P. Wilairat, P. Carr, L. J. Sutcliffe, S. Auparakkitanon,S. Alizadeh-Shekalgourabi, W. A. Moule, P. G. Evans, Exploration of Structure-Activity Relationships beteeen monomeric and dimeric 4-aminoquino9lines: Synthesis, Pharmacology & Molecular Modelling of Novel Antimalarials with activity in vivo. Gordon Conference: Malaria August 5-10, 2001, Queen's College, Oxford, UK. HTML/PDF 2000 Alizadeh-Shekalgourabi, S.; Dascombe, M. J.; Drew, M. G. B.; Ismail, F. M. D. Pharmacology, Spectroscopy and Molecular Modelling of Ro-47-7737. Presented at the Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (RSC), 11th Symposium of Medicinal Chemistry in Eastern England, Fielder Centre, Hatfield, U.K., 2000; Poster Presentation. M.J. Dascombe, M.G.B.Drew, H. Morris, P. Wilairat, S. Auparakkitanon, W. A. Moule, S. Alizadeh-Shekalgourabi, P. G. Evans, Ndrew. J. Blackaby, M. Lloyd, A. M. Dyas, P. Carr; Fyaz M. D. Ismail. Structural, Spectroscopic, Spectrometric and Biological properties of Synthetic 2,6-bispyrrolidin-yl methyl-phenol-9-amino-acridine Antimalarials: Pyronaridine and Pyracrine. Presented at the Biological and Medicinal Chemistry Sector (BMCS) of the Royal Society of Chemistry (RSC), 11th Symposium of Medicinal Chemistry in Eastern England, Fielder Centre, Hatfield, U.K., 2000; Poster Presentation. Manzel L, Strekowski L, ISMAIL F.M.D., Barlin, GB, Manzel L, Macfarlane DE Int. PCT Application: Antagonism of Immunostimulatory CPG-oligonucleotides by 4-aminoquinolines and other weak bases. WO0076982: Publication date: 2000-12-21: HTML/PDF ISMAIL F.M.D., Invited Lecture: A Deductive Approach to the Elucidation of Pharmaceutical Structures using Multi-dimensional NMR spectroscopy. One day meeting on Applications of NMR Spectroscopy to Food and Pharmaceutical Analysis" Thursday 23 March 2000, Cambridge, Royal Society of Chemistry: Anaytical Divison-East Anglia Region. Parveen, A. ISMAIL F.M.D.*, Invited Lecture, University of Hertfordshire: Applying Arapidopsis Thaliana as an Alternative model in metabolism studies of a novel antimalrial compound using HPLC as a detection method. Luck, J. A.. ISMAIL F.M.D.*, Invited Lecture, University of Hertfordshire: Comparitive drug metabolism studies of a normal antimalarial drug "metaquine" using HPLC analysis. 1999 Antagonism of immunostimulatory CpG-oligodeoxynucleotides by 4-aminoquinolines and other weak bases: Mechanistic studies Manzel L, Strekowski L, Ismail FMD, Smith JC, Macfarlane DE J. Pharmacol. Exp. Therapeut. 291 (3): 1337-1347 DEC 1999 HTML/PDF Mechanism of formation of benzothiazole-2-thiol Isaacs NS, ISMAIL, F.M.D.*, Hilton M.J.; Coulson, M. JOURNAL OF PHYSICAL ORGANIC CHEMISTRY, 1998, 11 (1): 1-9 Abstract PDF file Annual Review:Gateway to the new Era. University of Hertfordshire's Annual Review. 1999: Research into New Medicines for Malaria: ISMAIL F.M.D.* and M. J. Dascombe. HTML/PDF Invited Presentation: The rational Design and Synthesis& pharmacological evaluation of novel Metazaquines Team Leaders: ISMAIL F.M.D.* and M. J. Dascombe. Medicines for Malaria Venture. July 19-21, 1999,World Health Organisation, Geneva. Establishing the site of protonation in alkyl and aryl bridged bisquinoline drugs using crystallography: EPSRC Project No. 1999XR24 (in conjunction with The Department of Chemistry, The University of Southampton). GB Patent office. Novel bis-1,6-naphthyridines.Patent Application number 9914377.8 22 June 1999 Ref: PA 3371. Applicants: The University of Hertfordshire, The Victoria University of Manchester. GB Patent office. Novel bis-1,5-naphthyridines. Patent Application number 9914376.0 22 June 1999 Ref: PA 3370. Applicants: The University of Hertfordshire, The Victoria University of Manchester. 1998 Electron impact induced losses of HNO2 from trifluralin-phenylenediamine dimers mechanistic studies By Bhatt, Rakesh; Carr, Pamela; Frearson, Martin; Ismail, Fyaz; Advances in Mass Spectrometry (1998), 14, A016930/1-A016930/16.Elsevier Socrates Teaching Exchange Program: Exploring the potential of Novel Antimalarials Active in vivo. F. M. D.Ismail. 3 November, 1998. Laboratoire de Chimie Bio-Organique, University of Avignon, Faculte de Sciences, 3, rue Loisu Pasteur 84000 Avignon, France. Atterwill CK ; Purcell WM; ISMAIL F.M.D.*Targeted Antioxidants Int. PCT Appn. WO9834646 Publication date: 1998-08-13 HTML/PDF Poster Presentation: Ismail, F. M. D., Dascombe, M. J. Carr,P; Moule, W. A.;Alizadeh-Shekalgourabi,S; Evans, P. G. Mapping the functional in vivo antimalarial receptor. Gordon Conference: Malaria, Somerville College, Oxford, July 26-31, 1998 Abstract ISMAIL F.M.D.*, Dascombe MJ, Carr P, Merette SAM, Rouault P; Novel aryl-bis-quinolines with antimalarial activity in-vivo J PHARM PHARMACOL, 1998, 50 (5): 483-492. HTML/PDF PDF file MalariaReview: Prevention and Therapy (Emphasis on Africa) Yusof F, Audley BG, ISMAIL F.M.D., Walker JM A Rapid Assay for the Incorporation of Isopentyl Diphosphate in Rubber Biosynthesis; J. RUBBER RES. 1 (1): 48-66 1998. International Rubber Research Development Board Synthesis and pharmacological evaluation of novel potential antimalarials. (BL: DXN051973) Merette, S.A.M., 1998, G5a Ph.D., Hertfordshire, 52-1896 Abstract 1997 Frearson MJ, Bhatt R, Carr P, Frearson MJ, Bhatt R, Carr P, ISMAIL F.M.D. ; Electron impact induced elimination of HNO2 from trifluralin-phenylenediamine dimers - An ortho-effect resulting from a pi-pi interaction persisting into the vapour phase RAPID COMMUN MASS SP 11 (2): 201-205 1997. Abstract PDF file ISMAIL F.M.D. ; Parker, A. (Yew Tree Pharmaceuticals). Improvements in the Industrial production of Paclitaxel: A shorter ozonolytic route. ISMAIL F.M.D. ; T ISMAIL, F.M.D.*; Toad venom may find uses in the medicine. UH World of Natural Sciences; Special Issue, Global Networks, UH Press,1996, Hertfordshire, U.K. WebLink Molecular Modelling of pyronaridine: Ania Gwizdek, Fyaz M. D. Ismail and P. Carr: TEMPUS project between the University of Gdansk and the University of Hertfordshire. Additon of methyl groups to analogues of vitamin E (alpha-tocopherol) and comparing their relative dihedral angles on Macromodel: Meenesh P. Patel, Fyaz M. D. Ismail and P. Carr. 1996 ISMAIL F.M.D.* & Dascombe M.J.; Correlation of Biological Activity with NMR Spectral Parameters for Various Antimalarials. Poster presentation 12th December 1996, Division of Neursoscience, School of Biological Sciences, Stopford Building 1.124, University of Manchester M13 9PT, United Kingdom. ISMAIL F.M.D.*, Dascombe MJ. Poster presentation. Correlation of NMR Spectral parameters with biological activity of 1,2,4-trioxanes. RSC/SCI Medicinal Chemistry Symposium September 4-7, Churchill College, Cambridge, UK R. Bhatt, P. Carr, M. J. Frearson and F. M. D. ISMAIL. Poster Presentation to the British Mass Spectrometry Society, September 8th-11th, 1996. h SE; An Electron impact induced elimination of HNO2 from trifluralin-phenylenediamine dimers - An ortho-effect resulting from a pi-pi interaction persisting into the vapour phase PDF file F. M. D. ISMAIL*, Raza Mahmood, Philip G. Evans,and Elizabeth Conway: Oral Contribution: The Royal Society of Chemistry 6th International Meeting: Reaction mechanisms, July 9th-12th, 1996. University of Kent at Cantebury; A.5 A versatile Synthesi of Benzopyrans and Benzofurnas via an ortho-Claisen Rearrangement of Aryl-Allyl ethers. ISMAIL, F.M.D.*; Dascombe; M.J., Carr, P.; North, S.E; An exploration of the structure-activity relationships of 4-aminoquinolines: Novel antimalarials with activity in-vivo J. Pharm Pharmacol, 1996, 48, (8), 841-850. Abstract PDF file An exploration of electronic effects during the preparation of 4-aryl substituted quinolines. Patricia Roualt and Fyaz M. D. Ismail. Factors affecting the formation of rubber from isopentenyl pyrophosphate in Hevea brasiliensis latex (BL). Yusof, F., 1996, F6r Ph.D., Hertfordshire, 47-4220 Studies towards the synthesis of cardioactive steroids. Eric de Ronde M.Sc., University of Hertfordshire. Abstract Studies of the adducts and derivatives obtained from 1,3-dipolar cycloaddition reactions. Jones, A.E., 1996, D5d Ph.D., Hertfordshire, 46-4173 Abstract Hilton, P.J., White, R.W.; Lord,G.A.; Garner, G.V.; Gordon, D.B.; Hilton, M.J.; Forni, L.G.; McKinnon, W.; ISMAIL, F.M.D.; Keenan, M; Jones, K.; Morden, W.E. An inhibitor of the sodium pump obtained from human placenta LANCET 348 (9023): 303-305 AUG 3 1996. Abstract SummaryPlus/(HTML/PDF ) PDF file Invited lecture: ISMAIL F.M.D.*, Mahmood, R; Evans, P. G.; Conway, E. : A Versatile Synthesis of benzofurans and benzopyrans via an ortho-Claisen rearrangement of aryl-allyl ethers: Reaction Mechanisms: The Royal Society of Chemsitry, 6th International Meeting, University of Kent at Cantebury, 9-12 July, 1996. Abstract 1995 Synthesis of Novel Antimalarials with potential activity in vivo. Kristina Wade & Fyaz M. D. Ismail* . Synthesis of Bis-Quinoline compounds against Malaria. D.G. Garbe & Fyaz M. D. Ismail* . Synthesis of 7-substituted-1,2,3,4-terahydroquinolines. Nicolas F. Clairo & Fyaz M. D. Ismail* . 1993 The analysis and characterisation of novel mono- and bis- substituted amino-quinolines: A GC and HPLC study by Annie Bourseul & Fyaz M. D. Ismail. An investigation into the conformation of a tetroxane analogue of qinghaosu by A.Simpkins, P. Carr & Fyaz M. D. Ismail. The synthesis of brominated compounds as possible anticancer drug candidates by Ismail Kasujee & Fyaz M. D. Ismail. 1992 ISMAIL F.M.D.*, HILTON MJ, STEFINOVIC M; Versatile Synthesis of Benzopyrans via Ortho-Claisen Rearrangement of Allyl Ethers. Tetrahedron Letters 33 (26): 3795-3796 JUN 23 1992. Abstract PDF file 1990 ISMAIL F.M.D., Inhibition of Autoxidation in Amphipathic Systems, University of Salford, Lancashire, U.K., Ph.D Awarded 13/7/89: Chemical Abstracts 113:77497b(1990) Diss. Abstr. Int. B. (1990) 50 (10): 4539. Available from University Microfilms Int. Order No. BRD-86849 Abstract 1985 ISMAIL F.M.D., Richards,D. T.; Cundall, R. B. (1985) Pharmacotherapeutic and Dietary Approaches for Preventing Oxygen Toxicity in the Diving Mammal. SERC Marine Technology Directorate/Shell U.K. Ltd pp 1-10. Electronic papers: molecule of the month: RU486: Mifepristone, the morning afterpill. Contributions to "Org List" on the Web RE: ORGLIST:Nature of the TBA Chromogen WebLink RE: ORGLIST:Patent Searches WebLink RE: ORGLIST:Overpressure valves and vacuum lines WebLink RE: ORGLIST:Web-dictionary of Organic abbreviations? WebLink RE: ORGLIST:di-tert-butylamine WebLink RE: ORGLIST:Sources of Helpful Hints for Growing X-ray Quality Crystals? WebLink RE: ORGLIST:What is the Abramov reaction??? WebLink Medicinal and Illicit Uses of Toad Venoms WebLink