Synthesis of Unusual Trifluralin-Phenylenediamine dimers: Novel Scafolds leading to Compound with Leprostatic and Anticancer Activity Research team: F. M. D. Ismail, Dr M J Frearson, Dr P Carr, R Bhatt and N Saach (Pfizer) Programme of studies: This project involves the synthesis of novel trifluralin dimers that undergo interesting cyclisations both in the gas and solution phases. The compounds are structurally related to mauvine and the drug clofazimine which is currently used for the treatment of Dapsone resistant leprosy . Reference: Electron Impact Elimination of HNO2 from Trifluralin-Phenylenediamine dimers - An ortho effect Resulting from a pi-pi Interaction Persisting in the Gas Phase. M. Frearson*, R. Bhatt, P. Carr, and F. M. D. Ismail*, 1997, Rapid Communications in Mass Spectrometry . Vol. 11, , pp 201-205.

Lowest energy conformer of Mauveine A acetate, as elucidated by Meth-Cohn and Smith (1994), a major component of the dye mauve, first synthesised by Perkin from impure aniline. Molecules Maintained By W.A.Moule (B.Sc, Hons), Head of Molecular Modelling, Medicinal Chemistry Research Group.