Current Research Activities Synthesis of An Inhibitor of the Sodium Pump Obtained From Human Placenta Molecular Modelling and Visualisation of Chemical Structures Molecular Modelling & Structure-Activity Relationships of 4-Amino-mono and bis-Quinolines: Novel Antimalarials with Activity in vitro and in vivo Molecular Modelling & Structure-Activity Relationships of pyronaridine: Novel Benz-naphthyridine Antimalarials with Activity in vitro and in vivo Synthesis of Unusual Trifluralin-Phenylenediamine dimers: Novel Scafolds leading to Compound with Leprostatic and Anticancer Activity Reactions exploiting Ortho-Claisen Rearrangement of Allyl Ethers:Synthesis of Benzofurans and Benzopyrans in Near Superacid Media Synthesis of Dimeric Benzodiazepines Optimisation of the Kelly Process Critical Reviews of Medicines in Current Use

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Correlation of Spectral, Molecular Modelling with Biological Activity of Certain Trioxanes related to Qinghaosu Research team: F. M. D. Ismail, and Dr P Carr Programme of studies: Artemisinin is an antimalarial compound that has other biological activities such as healing psoriatic lesions. Importantly, biological activity data correlated with structure (using molecular modelling), Using a diverse range of 1,2-dioxolanes and 1,2,4-trioxanes,revealed minimum pharmacophoric requirements whilst maintaining biopotency. This approach has been succesfully used to identify several new potent antimalarials constructed using radical cascade reactions. Products are characterised using multidimensional high field 2-D NMR experiments.

Lowest energy conformer of Artemisinin a potent sesquiterpene endoperoxide antimalarial active in vivo Molecules Maintained By W.A.Moule (B.Sc, Hons), Head of Molecular Modelling, Medicinal Chemistry Research Group.